Heritable bipolar phenotypes pinned down

A very interesting perspective.

Manic Muses

(I don’t usually quote an entire article, but this subject is near and dear to my heart….)

Heritable bipolar phenotypes pinned down

Published on February 14, 2014 at 5:12 PM

By Eleanor McDermid, Senior medwireNews Reporter

A large study has pinpointed brain and behavioural traits that are genetically influenced and associated with bipolar I disorder.

Carrie Bearden (University of California, Los Angeles, USA) and team examined 169 behavioural, neurocognitive and neuroimaging traits in 181 patients with bipolar I disorder and their close relatives – 738 people in total.

They found that three-quarters of these traits were heritable, 31% were significantly associated with bipolar disorder and 24% were both heritable and associated with bipolar disorder.

Traits in this last group “are the most promising phenotypes for identifying loci contributing to disease risk, as shown for other neuropsychiatric disorders,” write the researchers in JAMA Psychiatry.

They add: “Some phenotypes in this…

View original post 323 more words

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